Peyronie’s Disease

Peyronie’s disease is where plaques (segments of flat scar tissue) form under the skin of the penis. These plaques can cause the penis to bend or become indented during erections. The plaques can often be felt through the skin and can be painful.

Other signs that you may have Peyronie’s disease are:

    • bent/curved penis
    • lumps in the penis
    • painful erections
    • soft erections
    • having trouble with sex because of a bent/curved penis

Peyronie’s disease can make your quality of life worse. Over 75 out of 100 men with Peyronie’s disease are stressed and depressed because of it. Unfortunately, many men with Peyronie’s disease are embarrassed and choose to suffer in silence rather than get help.


Peyronie’s disease is usually caused by minor injury to the penis. This type of damage is most often caused by vigorous sex (such as bending the penis during penetration or pressure from a partner’s pubic bone), though it can also be caused by sports or other accidents. 


You will be evaluated with a physical exam to check for palpable scarring or plaque. The hard plaques can most often be felt whether the penis is stiff or not.

To check how the penis curves, we may inject a drug into your penis to make it stiff and perform a dynamic ultrasound, which uses sound waves to get a picture of what is in your body, is used to see where the plaque is, check for calcium buildup and show how the blood flows in your penis. This study is easily performed in the office.


In a very few cases (about 13 out of 100), Peyronie’s disease goes away without being treated. Most health care experts suggest treating the disease without surgery for the first 12 months after the disease is first noticed. Men with small plaques, not much curving of the penis, no pain and no problems with sex may not need to be treated. If you need to be treated, there are many choices.

Drug therapy may help men who are badly affected by the disease during the acute phase. Most society guidelines do not recommend oral drugs because long-term studies have not shown convincing benefit.

Injecting a drug right into the plaque brings higher doses of the drug to the problem than when a drug is taken by mouth. Plaque injection is often used for men with early Peyronie’s disease or those who aren’t sure they want to have surgery. 

Injection options include verapamil injections, interferon injections and collagenase injections.

Collagenase is made in the body and breaks down certain scar tissues. Studies have shown that injecting collagenase into plaques helped fix Peyronie’s disease. This drug is now approved in the U.S. by the FDA for treatment of men with penises curving more than 30 degrees.


For useful information on collagenase injection option in office please refer to:

Other ways to treat Peyronie’s disease are being studied. But there isn’t enough data on them yet to prove they work.

Some small studies have shown that stretching the penis daily for at least 6 months may help restore length and curving.

Treating the penis with ultrasound, radiation, shockwaves, heat and verapamil on the skin are also being studied. These, for the most part, are not proven and are not recommended by experts in the field.

Surgery for Peyronie’s Disease

Surgery is reserved for men with more severe, disabling penile deformities that make it hard to have sex.

There are 3 basic ways to fix Peyronie’s disease with surgery:

  • making the side of the penis opposite the plaque shorter
  • making the side of the penis that curves longer
  • placing a prosthetic device inside the penis if the man has both Peyronie’s disease and erectile dysfunction

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